Medico Research Chronicles <p style="text-align: justify;"><code></code>Medico Research Chronicles (Medrech) ISSN No. <a href="">2394-3971</a>, is an official journal of Medico Edge Publications. It is a peer-reviewed, open-access journal of medical and health sciences, published on bi-monthly intervals. It publishes various manuscripts on the diverse specialization of medical, health science, and clinical research.</p> <p>Indexed by the&nbsp;&nbsp;<a href=""><strong>United States'&nbsp;NLM Catalogue, NCBI</strong></a></p> <p><strong>Medico Research Chronicles has been positively evaluated by <a href="">Index Copernicus</a>, Poland for the year 2019 and assigned an IC Value of 78.67.&nbsp;</strong></p> <p><strong>Journal is valid for publication as per MCI Guidelines. A transitory period of 2 years (Upto 2022) is given for consideration of publication.&nbsp;</strong></p> <p><strong>Academicians and Researchers interested in reviewing the article are requested to join us on Publons: <a title="Publons by Web of Science" href=""></a></strong></p> <p><strong><a href="">Click Here </a></strong>for the notification details.</p> <p>&nbsp;</p> Medico Edge Publications en-US Medico Research Chronicles 2394-3971 Anomalies of the genetic complement and its role in C3 Glomerulopathies and development of Hemolithic Uremic Syndrome <p>Let us remember that C3 glomerulopathy is the product of an abnormal activation in the alternative complement pathway, which leads to an excessive production of active C3 and its degradation products</p> Juan Esteban Tafur Delgado Carlos Andrés Pérez Lozano Lina Marcela Ortiz Roncallo Silvia Juliana Rodríguez Pérez Amaury Gustavo López Agámez María José Álvarez Gómez Ricardo Javier Galván Zúñiga Ana María Garcés Pérez Copyright (c) 2021 Juan Esteban Tafur Delgado, Carlos Andrés Pérez Lozano, Lina Marcela Ortiz Roncallo, Silvia Juliana Rodríguez Pérez, Amaury Gustavo López Agámez, María José Álvarez Gómez, Ricardo Javier Galván Zúñiga, Ana María Garcés Pérez 2021-07-20 2021-07-20 8 4 303 304 Five-year spatiotemporal distribution of malaria in hotspot and Ivermectin mass-drug administration zone of Amhara Regional State, Ethiopia <p><strong>Objectives</strong>: Evaluate the Spatiotemporal distribution of malaria in the hotspot and Ivermectin mass-drug administration Zone of Amhara Regional State, Ethiopia. Study Design: A descriptive prevalence study design was used.</p> <p><strong>Methods:</strong> - A 25 study sources were incorporated in the survey. Purposive sampling techniques were utilized. Data were obtained by the standard format of systematic evaluation of four surveillance units from January to August 2020 through observation, document review, and interviewing surveillance officers and focal persons using a semi-structured Survey. The statistical analysis, tabular, and graphical output are generated using the open-source statistical program R.</p> <p><strong>Results:</strong> - Average report fullness and aptness were 97.9% and 96% respectively. The average annual malaria incidence rate was a decline in terms of place and time, from the year 2015 to 2019 with an average reduction rate of 5.5% and the average annual parasitic incidence rate was 52 (22-199). In 2019/2020, 43,131 malaria cases were reported in the zone. The study identifies no program-specific supportive supervision of public health emergency management and no routine data analysis and was not used for decision making.</p> <p><strong>Conclusion:</strong> This result revealed that the malaria incidence rate showed a remarkable decline. However, the annual parasitic incidence rate remains constant. This indicates that ivermectin did not affect malaria elimination. Hence, the districts and sub-city health offices should conduct regular surveillance data analysis, perform supportive supervision, avail budgets and further laboratory investigations should be done to investigate the effect of ivermectin on the parasites under laboratory conditions.</p> Chalachew Yenew Sileshi Mulatu Copyright (c) 2021 Chalachew Yenew*, Sileshi Mulatu 2021-07-21 2021-07-21 8 4 305 312 To Study about prescription patterns for bronchial asthma by allopathy doctors in Agra region <p><strong>Background:</strong> Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. Patients with asthma require lifelong treatment and multiple anti-asthmatic drugs at the same time. Drug utilization audits are quality assurance programs to ensure that drugs are used correctly and safely. This&nbsp; study was done by conducting prescription audits and identifies irrationality in drug prescribing.</p> <p><strong>Material and Methods</strong>: To assess the prescription pattern of bronchial asthma by allopathic doctors of the Agra region among patients visiting Sarojini Naidu medical college, Agra. Data were collected from patients suffering from bronchial asthma having, at least one written prescription by previous treating doctors. The sample size of the study was 122.</p> <p><strong>Results:</strong> In this study, Assessment of prescription pattern of bronchial asthma by allopathy doctors,&nbsp;&nbsp; among 122&nbsp;&nbsp; prescriptions, most of the prescriptions 64% belong to general practitioners and 36% belong to specialists. In this study, Assessment of prescription pattern of bronchial asthma by allopathy doctors,&nbsp;&nbsp; among 122&nbsp; bronchial asthma patients prescriptions, most of the prescriptions 62%&nbsp; prescriptions were not according to GINA and 38%prescriptions were according to GINA.</p> <p><strong>Conclusion: </strong>In conclusion, National Asthma Education Program will be beneficial as an initial step, in improving asthma knowledge and increasing awareness in the medical community, on current therapy. This study may be more meaningful to improve further the prescriptions through successful implementation of the interventional programs in the health care centers.</p> Santosh Kumar Gajendira Vikram Singh Sachin Kumar Gupta Aravind R Komal Lohchab Achal Singh Bhanu Pratap Pandey Rajeev Kumar Chauhan Amiral Haque Vipin Kumar Copyright (c) 2021-08-03 2021-08-03 8 4 313 316 10.26838/10.26838/MEDRECH.2021.8.4.545 Comparison of sensory and motor block outcome of fractionated versus single bolus dose administration of hyperbaric bupivacaine in elective cesarean section <p><strong>Introduction:</strong> To achieve the best anesthetic outcome in pregnant women undergoing cesarean deliveries, spinal anaesthesia is the most popularly preferred method. The present study assessed the sensory and motor blockade outcome, following the administration of single bolus dose versus fractionated dose of bupivacaine as spinal anesthesia, in terms of the time of onset and regression, in cesarean section deliveries. <strong>Methods:</strong> With ethical approval from the corresponding authority and informed written consent from the patients, this study included 100 randomly selected, singleton, non-complicated pregnant women admitted in the Combined Military Hospital (CMH), Dhaka, during the period of July 2018 to June 2019, for elective LUCS. Patients were randomly divided into two equal groups- Group A and Group B, each comprised of 50 patients. Following the standard protocol to administer spinal anesthesia, Group A patients were given a single bolus dose of bupivacaine over 10 seconds and Group B patients were given fractionated dose of bupivacaine with two-third of the total calculated dose given initially, followed by one-third dose after 90 seconds. The age, height and physical status of the patients, the time of onset and regression of sensory and motor block were assessed and recorded. The post-operative pain was assessed with the linear visual analog scale (VAS) every 30 min after surgery for the first 2 hours then hourly up to 6 hours and the duration of analgesia was recorded. All the data has been analyzed with the help of IBM SPSS software (Statistical Package for Social Science) version-22. <strong>Results</strong>: The mean of the onset of sensory and motor block was faster in Group A than in group B, in case of sensory block onset it was 1.6 ± 0.5 min in Group A and 2.3± 0.8 min in Group B and in case of motor block onset it was 5.4 ± 1.1 min in Group A and 5.9± 1.2 min in Group B (p&gt;0.05). The duration of sensory (Group A: 143.5 ± 23.7, Group B: 212.7 ± 38.6) and motor block (Group A: 118.5 ± 22.5, Group B: 175.2 ± 28.3 was significantly higher in group B than in group A, (p&lt;0.05). Group A patients had a significantly higher mean of the VAS score than Group B patients at each time point (p&lt;0.05). The mean of the duration of analgesia was statistically significantly higher in Group B (235.1± 29.2) than in Group A (198.5±21.3) (p&lt;0.05). <strong>Conclusion: </strong>This study concludes with the findings that, fractionated administration of bupivacaine in spinal anesthesia provides better aesthetic outcomes in terms of prolonged duration of sensory and motor block.</p> Sabiha Mahbuba Md. Mohiuddin Majed Chy Sharmin Naz Maksuda Begum Shah Saroar Jahan Zubyeer Ali Sheikh Copyright (c) 2021 Lt Col Sabiha Mahbuba, Md. Mohiuddin Majed Chy, Sharmin Naz, Maksuda Begum, Shah Saroar Jahan, Zubyeer Ali Sheikh 2021-08-06 2021-08-06 8 4 317 324 10.26838/MEDRECH.2021.8.4.544 Pulmonary arterial hypertension in patients of healed pulmonary Tuberculosis and its association with quality of life <p><strong>Background:</strong> pulmonary tuberculosis leads to pulmonary impairment after tuberculosis leads to pulmonary impairment (obstructive, restrictive, and mixed) which changed the quality of life of these patients.</p> <p><strong>Objective</strong>: To study Pulmonary arterial hypertension in patients of healed pulmonary tuberculosis and its association with quality of life.</p> <p><strong>Material and Methods:</strong> Sputum for AFB under NTEP, X-ray chest PA view, ECG, 2d-echocardiography, six-minute walk test, Saint George's Respiratory Questionnaire.</p> <p><strong>Results:</strong> Symptoms score, Activity score, Impact score, total score were compared among cases those developed PAH and those who not developed and interpretation was p-value of .018, .0349, .0969, .0369 respectively.</p> <p><strong>Conclusion:</strong> Pulmonary impairment after tuberculosis is a major health-related problem. We should not focus only on managing active cases of pulmonary tuberculosis but should consider pulmonary impairment after tuberculosis that means post tubercular lungs need a relook. These patients should undergo proper and early screening, diagnosis, and correct recognition of the pattern of pulmonary impairment (obstructive, restrictive, and mixed) which will provide proper guidance for comprehensive management of these patients and thereby improving quality of life.</p> Gajendra Vikram Singh Santosh Kumar Bhanu Pratap Pandey Sachin Kumar Gupta Achal Singh Aravind Rajeev Kumar Chauhan Amirul Haque Vipin Kumar Copyright (c) 2021 Gajendra Vikram Singh, Santosh Kumar, Bhanu Pratap Pandey, Sachin Kumar Gupta, Achal Singh, Aravind, Rajeev Kumar Chauhan, Amirul Haque, Vipin Kumar 2021-08-06 2021-08-06 8 4 325 333 10.26838/MEDRECH.2021.8.4.546 The at-home delivery of treatment for benign prostate enlargement and chronic prostatitis enabled by Dr Allen’s Device is a valuable healthcare innovation during a pandemic <p><strong>Introduction:</strong> The Coronavirus (COVID-19) outbreak has demonstrated the need for a novel delivery of treatment for benign prostate enlargement (BPE) and chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS). Their standard treatments with medications and surgeries require extensive contact between patients and healthcare professionals that worsens a pandemic. This study aims to determine whether therapeutic Dr Allen’s Device (DATD) and Thermobalancing therapy (TT) can be used as an effective self-management tool and at-home treatment for chronic prostate diseases.</p> <p><strong>Methods:</strong> This is a retrospective cohort study of 45 men with CP/CPPS and 124 men with BPE who were observed before and after applying TT with DATD at home for 6 months in 2 clinical controlled trials. The dynamics of clinical characteristics and parameters, such as pain, urinary symptoms, quality of life (QoL), and prostate volume (PV) were compared to the control groups without DATD.</p> <p><strong>Results:</strong> DATD reduced pain scores from 10.3 to 3.5 (P&lt;0.001) in men with CP/CPPS. In men with BPE, DATD reduced PV from 45mL to 31mL (P&lt;0.001) and urinary symptoms from 14.3 to 4.9 (P&lt;0.001). DADT significantly improved QoL in both treatment groups. In the control groups, no positive changes were observed.</p> <p><strong>Conclusions:</strong> The use of DATD with TT relieves chronic pelvic pain and reduces an abnormal prostate size in patients with CP/CPPS and BPE, improving their QoL and wellbeing. Thus, DATD is an effective at-home self-management tool and provides a novel delivery of treatment for non-cancerous prostatic diseases, especially important during a pandemic.</p> A Adjani S Allen Copyright (c) 2021 Adjani A, Allen S 2021-08-09 2021-08-09 8 4 334 344 10.26838/MEDRECH.2021.8.4.542 Depression among elderly living in old age homes and its association with other factors <p>With a progressively ageing population worldwide, treatment and identification of depression in older adults become increasingly important, particularly as older people have distinct presentations and needs than younger ones Depression with the elderly constitutes a serious public health problem that attracts worldwide interest. The goal of this particular study is actually estimating the prevalence of depression and its associated aspects among community-dwelling aged. It's a cross-sectional analysis in which 203 aging adult individuals residing in old age homes of Delhi, India was selected arbitrarily. The job interview was completed using the socio-demographic tool, Geriatric Depression Scale (GDS), ICD 10 DCR, Duke interpersonal assistance scale, UCLA loneliness scale, as well as Barthel index was used. This particular study offers an astonishing signal for overall health professionals as well as wellness policy developers in India for the demand of a much better recognition of depressive symptoms in elderly.</p> Shreya Suman Dhanda Copyright (c) 2021 Dr. Shreya, Dr. Suman Dhanda 2021-08-09 2021-08-09 8 4 345 350 10.26838/MEDRECH.2020.8.4.547 Relationship between depression and health-related behaviors of male senior college students <p>Depression is a typical psychological condition that is extremely common in the overall public and it is a significant contributor to the all-around global burden of illness. A cross-sectional analysis design was used utilizing a structured questionnaire to determine depression and health-related action in male adolescents. Gender differences occur in the improvement of depression, and those differences are particularly prominent during adolescence. The data had been collected from pupils of a senior college in using convenience sampling to choose the participants. The results established the connection between depression and health-related actions. The growth of health-related habits might help in lowering depressive symptoms.</p> Shreya Suman Dhanda Copyright (c) 2021 Dr. Shreya, Dr. Suman Dhanda 2021-08-11 2021-08-11 8 4 351 356 Knowledge about the risk factors and sign-symptoms of cardiovascular diseases among the patient's attendants at a specialized hospital in Bangladesh <p><strong>Background</strong>: Now a day, cardiovascular disease (CVD) is a very common disease in Bangladesh. Hypertension is the most widely prevalent, largely preventable risk factor for CVD accounting for half of the deaths due to ischaemic heart disease and stroke. Therefore, due to CVD and CKD, uncontrolled hypertension has huge implications for the disease burden. In today’s world, awareness among people about the risk factors, signs symptoms, and prevention of CVD is considered as one of the most potent components in saving people from huge mortalities and morbidities of CVD. Aim of the study: The present study aimed to assess the knowledge about the risk factors and sign symptoms of cardiovascular diseases among the patient's attendants in the NICVD (National Institute of Cardiovascular Disease) Dhaka, Bangladesh. <strong>Methods:</strong> This was a cross-sectional study. The study was conducted at a National Institute of Cardiovascular Disease (NICVD) in Dhaka, Bangladesh in collaboration with the Department of Public Health, Northern University, Dhaka, Bangladesh during the period from September 2017 to December 2017. Properly written consent was taken from all the participants before starting data collection. A pre-designed questioner was used to collect data. All the results were calculated with the help of a computer by using the SPSS 22.0 version. Data were presented according to the variable of the study and shown in percentage. <strong>Results:</strong> In this study maximum, 83.2% of respondents knew the risk factor of CVD but 16.8% had not. Among the total participants, the major risk factor of CVD hypertension was defined by 80%, smoking by 73%, alcoholism by 53%, DM by 50%, high fat diet by 52%, and family history of diabetes by 34% of respondents. The maximum, 79.2% respondents had the idea of the sign-symptoms of CVD whereas 20.9% had not. As sign/symptoms maximum, 94% of respondents defined chest pain as the major whereas 48% defined shortness of breathing, 39% defined sweating, 36% defined vomiting and 12% defined swelling as the sign/symptoms of CVD. This study revealed that 55.4% of respondents had knowledge regarding the prevention of CVD but 26.7% had not. <strong>Conclusion:</strong> The knowledge about the risk factors and significant symptoms of cardiovascular diseases (CVD) among the patient's attendants in Bangladesh may not be considered satisfactory. So, there are many scopes to do more works on awareness development about CVD among the general population in Bangladesh.</p> Lt Col(Dr.) Sohel Hasan Chowdhury Royena Tabassum Rebeaka Tarannum Shafiqul Kabir Copyright (c) 2021 1Lt Col(Dr.) Sohel Hasan Chowdhury, Dr. Royena Tabassum, Dr. Rebeaka Tarannum, Prof. Shafiqul Kabir 2021-08-30 2021-08-30 8 4 363 369 A review on the use of corticosteroids <p>corticosteroids [CS] are used to treat various diseased conditions such as inflammatory diseases including allergic diseases and hypersensitivity reactions. Cortisol is produced in the adrenal gland and a variety of other hormones are produced through cholesterol metabolism. They are elaborated in the regulation of different processes such as metabolism electrolyte regulation inflammation, and stress responses based on their major effects. Corticosteroids acts as anti-inflammatory, antiproliferative, immunosuppressive and shows vasoconstrictive effects. Prolonged use of&nbsp; corticosteroid leads to hormonal changes within the body which may cause a wide range of side effects. Once corticosteroids are prescribed the patient should be monitored regularly and reviewed to assess the response to the treatment with adjusting the dose at a minimum. When corticosteroids are used thoroughly as intensive therapy or for prolonged courses, a tapering strategy is recommended to prevent signs and symptoms of adrenal insufficiency due to hypothalamic-pituitary-adrenal axis suppression.</p> Sushrutha Kanaparthi Copyright (c) 2021 Sushrutha Kanaparthi 2021-08-16 2021-08-16 8 4 357 362 10.26838/MEDRECH.2020.8.4.543